Target: NS3/4A Protease | Disease State: Hepatitis C

Introduction / Brief Description

Danoprevir is a small molecule inhibitor of the hepatitis C virus NS3/4A protease, invented by Array initially for InterMune. Roche acquired danoprevir from InterMune in 2010 and Ascletis Pharmaceuticals Co. Ltd., gained China rights for danoprevir from Roche in 2013. InterMune has an obligation to make milestone payments to Array based on the selection and progress of danoprevir, as well as royalties on commercial sales of danoprevir. To date, Array has received $4.2 million in milestone payments and has the potential to earn an additional $5 million if all clinical and commercialization milestones for danoprevir are achieved under the agreement. In June 2018, the China Food and Drug Administration (CFDA) approved danoprevir (trade name, Ganovo®) for the treatment of viral hepatitis C.

Clinical Trials

To learn more about danoprevir clinical trials, click here.  

Publications and Presentations



Journal of Medicinal Chemistry

Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease

Y. Jiang, et al.

To view all publications, click here.

These compounds and their uses are investigational and have not been approved by the U.S. Food and Drug Administration. This information is presented only for purposes of providing a general overview of our clinical trials.