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Ipatasertib

10/14/2012

International Society for the Study of Xenobiotics North American Regional Meeting

Preclinical ADME Evaluation of GDC-0068, a Novel, ATP-competitive Akt Inhibitor

B. M. Liederer, et al

Ipatasertib

09/28/2012

European Society for Medical Oncology Congress

Phase Ib Dose Escalation Study of the Akt Inhibitor GDC-0068 with Docetaxel or mFOLFOX6 in Patients with Advanced Solid Tumors

J.C. Bendell, et al.

Ipatasertib

08/30/2012

Journal of Medicinal Chemistry

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

J. F. Blake, et al.

Ipatasertib

07/18/2012

Organic Reactions and Processes, Gordon Research Conference

Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate in ARRY-452/GDC-0068

J. Lane, et al.

Ipatasertib

06/04/2012

American Society of Clinical Oncology Annual Meeting

A Phase Ib/II Study Testing the Safety and Efficacy of Combined Inhibition of the PI3K/Akt and Androgen Receptor Signaling Pathways in Castration-resistant Prostate Cancer: GDC-0068 or GDC-0980 with Abiraterone Acetate Versus Abiraterone Acetate

R. Funke, et al.

Ipatasertib

06/02/2012

American Society of Clinical Oncology Annual Meeting

A Phase Ib Study of the Akt Inhibitor GDC-0068 with Docetaxel or mFOLFOX6 in Patients with Advanced Solid Tumors

C. Saura, et al.

Ipatasertib

06/07/2011

Cambridge Healthtech Institute Next Generation Kinase Inhibitors

Discovery of GDC-0068: A Selective ATP-competitive Akt Inhibitor for the Treatment of Human Tumors

J. F. Blake, et al.

Ipatasertib

03/11/2011

International Symposium on Targeted Anticancer Therapies

Targeting the PI3K-Akt-mTOR pathway with GDC-0068, a novel selective ATP competitive Akt inhibitor

J. Tabernero, et al.

Ipatasertib

09/23/2010

PLoS ONE

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

W. Wu, et al.

Ipatasertib

08/13/2010

Bioorganic & Medicinal Chemistry Letters

Discovery of pyrrolopyrimidine inhibitors of Akt

James F. Blake, et al.